克羅米酚對男性較差促性腺素性功能減退症有效

紐約市（早些時候衛生特别版）1同年四日報道：據登載在12同年出特别版的《生育與生孩子》雜志的一項調查結果援引克羅米胺對一小低促性腺素性基本功能大不如前的未幼小病症十分困難。來自伯明翰新澤西大學的該調查結果的第一作者Scott J. Whitten哈佛大學在接受路透新聞社采訪時說道：“原發性或獲得性HH病症在接受觸犯性相當大和更爲昂貴的放射治療（例如注射促性腺激素類）以前同步進行4個同年的克羅米胺試驗性放射治療是十分困難的。”Whitten哈佛大學和同事學術研究了克羅米胺對10名HH未幼小病症（HH是導緻未幼小生孩子的少見因素）是否有效。調查結果引述克羅米胺放射治療1年後，4名貝爾(高氏)綜合症病症裏面隻有一名病症的生殖溶解度增加而全小腦基本功能大不如前症病症的生殖缺少症狀均未得到改善。相反，該調查結果援引3名幼小中風的原發性HH未幼小病症經過3個同年克羅米胺的放射治療生殖溶解度有了明顯增加。目以前爲止該組病症才有兩名完全恢複了受孕。Whitten哈佛大學說道：“除非對克羅米胺放射治療未反應，我們不會因爲征狀終止對病症使用該藥物。”最後作者概述說道：“因爲條件有限，對HH病症促性腺激素類藥物和克羅米胺的随機學術研究不足以同步進行，然而利用多系列的嚴格同樣基準對病症同步進行分級可能試圖進一步驗證克羅米胺完全恢複未幼小低受孕的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

編輯：藍色幻想

編輯： 張靖